A magnitude-6.2 earthquake jolted a remote and mountainous region on the northern edge of the Qinghai-Tibetan plateau just before midnight on Monday, killing at least 118 people and injuring hundreds, according to Chinese state media,
Reuters reports.
Authorities have mobilised an array of emergency responses, but rescue work has proved challenging in subzero temperatures. Most of China was grappling with freezing temperatures as a cold wave swept across the country.
Earthquakes are common in western provinces such as Gansu which lie on the eastern boundary of the Qinghai-Tibetan plateau, a tectonically active area. China's deadliest quake in recent decades was in 2008 when a magnitude-8.0 temblor struck Sichuan, killing nearly 70,000 people.
At 11:59 p.m. local time (1559 GMT) on Monday, the latest quake struck Jishishan county in Gansu at a depth of 10 km (6.2 miles), according to China Earthquake Networks Center (CENC).
The epicentre was 5 km from the border between Gansu and a neighbouring province, Qinghai, where strong tremors were also felt.